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Structure paper

TitlePushed to extremes: distinct effects of high temperature vs. pressure on the structure of an atypical phosphatase.
Journal, issue, pagesBiorxiv, Year 2023
Publish dateApr 24, 2023 (structure data deposition date)
AuthorsGuerrero, L. / Ebrahim, A. / Riley, B.T. / Kim, M. / Huang, Q. / Finke, A.D. / Keedy, D.A.
External linksBiorxiv / PubMed:37205580
MethodsX-ray diffraction
Resolution1.71 - 1.96 Å
Structure data

PDB-8sls:
Crystal structure of human STEP (PTPN5) at cryogenic temperature (100 K) and ambient pressure (0.1 MPa)
Method: X-RAY DIFFRACTION / Resolution: 1.71 Å

PDB-8slt:
Crystal structure of human STEP (PTPN5) at physiological temperature (310 K) and ambient pressure (0.1 MPa)
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

PDB-8slu:
Crystal structure of human STEP (PTPN5) at cryogenic temperature (100 K) and high pressure (205 MPa)
Method: X-RAY DIFFRACTION / Resolution: 1.84 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / PTPN5 / STEP / Phosphatase

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