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Title | Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 255, Page 115385-115385, Year 2023 |
Publish date | Jan 17, 2023 (structure data deposition date) |
![]() | Ghosh, A.K. / Mishevich, J.L. / Kovela, S. / Shaktah, R. / Johnson, M. / Wang, Y.F. / Wong-Sam, A. / Agniswamy, J. / Amano, M. / Takamatsu, Y. ...Ghosh, A.K. / Mishevich, J.L. / Kovela, S. / Shaktah, R. / Johnson, M. / Wang, Y.F. / Wong-Sam, A. / Agniswamy, J. / Amano, M. / Takamatsu, Y. / Hattori, S.I. / Weber, I.T. / Mitsuya, H. |
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Methods | X-ray diffraction |
Resolution | 1.12 - 1.25 Å |
Structure data | ![]() PDB-8fui: ![]() PDB-8fuj: |
Chemicals | ![]() ChemComp-Y9R: ![]() ChemComp-NA: ![]() ChemComp-CL: ![]() ChemComp-ACT: ![]() ChemComp-GOL: ![]() ChemComp-FMT: ![]() ChemComp-HOH: ![]() ChemComp-Y9N: |
Source |
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![]() | HYDROLASE/INHIBITOR / ![]() ![]() |