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-Structure paper
タイトル | Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy. |
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ジャーナル・号・ページ | Acta Neuropathol Commun, Vol. 11, Issue 1, Page 74, Year 2023 |
掲載日 | 2023年5月5日 |
![]() | Chao Qi / Masato Hasegawa / Masaki Takao / Motoko Sakai / Mayasuki Sasaki / Masashi Mizutani / Akio Akagi / Yasushi Iwasaki / Hiroaki Miyahara / Mari Yoshida / Sjors H W Scheres / Michel Goedert / ![]() ![]() |
PubMed 要旨 | Subacute sclerosing panencephalitis (SSPE) occurs in some individuals after measles infection, following a symptom-free period of several years. It resembles chronic traumatic encephalopathy (CTE), ...Subacute sclerosing panencephalitis (SSPE) occurs in some individuals after measles infection, following a symptom-free period of several years. It resembles chronic traumatic encephalopathy (CTE), which happens after repetitive head impacts or exposure to blast waves, following a symptom-free period. As in CTE, the neurofibrillary changes of SSPE are concentrated in superficial cortical layers. Here we used electron cryo-microscopy (cryo-EM) of tau filaments from two cases of SSPE to show that the tau folds of SSPE and CTE are identical. Two types of filaments were each made of two identical protofilaments with an extra density in the β-helix region. Like in CTE, the vast majority of tau filaments were Type I, with a minority of Type II filaments. These findings suggest that the CTE tau fold can be caused by different environmental insults, which may be linked by inflammatory changes. |
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手法 | EM (らせん対称) |
解像度 | 2.3 - 3.7 Å |
構造データ | EMDB-16532, PDB-8caq: EMDB-16535, PDB-8cax: |
由来 |
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![]() | PROTEIN FIBRIL / Tau filament / ![]() ![]() |