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TitleClp-targeting BacPROTACs impair mycobacterial proteostasis and survival.
Journal, issue, pagesCell, Vol. 186, Page 2176-, Year 2023
Publish dateOct 6, 2022 (structure data deposition date)
AuthorsHoi, D.M. / Junker, S. / Junk, L. / Schwechel, K. / Fischel, K. / Podlesainski, D. / Hawkins, P.M.E. / van Geelen, L. / Kaschani, F. / Leodolter, J. ...Hoi, D.M. / Junker, S. / Junk, L. / Schwechel, K. / Fischel, K. / Podlesainski, D. / Hawkins, P.M.E. / van Geelen, L. / Kaschani, F. / Leodolter, J. / Morreale, F.E. / Kleine, S. / Guha, S. / Rumpel, K. / Schmiedel, V.M. / Weinstabl, H. / Meinhart, A. / Payne, R.J. / Kaiser, M. / Hartl, M. / Boehmelt, G. / Kazmaier, U. / Kalscheuer, R. / Clausen, T.
External linksCell / PubMed:37137307
MethodsX-ray diffraction
Resolution2 - 2.25 Å
Structure data

PDB-8b9o:
Structure of the C-terminal domain of ClpC2 from Mycobacterium smegmatis
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-8b9u:
Structure of ClpC1 NTD from Mycobacterium tuberculosis
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-RPI:
phospho-arginine

ChemComp-HOH:
WATER

ChemComp-FMT:
FORMIC ACID

Source
  • mycolicibacterium smegmatis (bacteria)
  • mycobacterium tuberculosis (strain atcc 25618 / h37rv) (bacteria)
  • nonomuraea sp. mjm5123 (bacteria)
KeywordsCYTOSOLIC PROTEIN / stress resistance protein / CHAPERONE / ligand bound state

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