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Structure paper

TitleCD4 + T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity.
Journal, issue, pagesImmunity, Vol. 56, Page 1082-1097.e6, Year 2023
Publish dateDec 3, 2021 (structure data deposition date)
AuthorsCiacchi, L. / van de Garde, M.D.B. / Ladell, K. / Farenc, C. / Poelen, M.C.M. / Miners, K.L. / Llerena, C. / Reid, H.H. / Petersen, J. / Price, D.A. ...Ciacchi, L. / van de Garde, M.D.B. / Ladell, K. / Farenc, C. / Poelen, M.C.M. / Miners, K.L. / Llerena, C. / Reid, H.H. / Petersen, J. / Price, D.A. / Rossjohn, J. / van Els, C.A.C.M.
External linksImmunity / PubMed:37100059
MethodsX-ray diffraction
Resolution2.8 - 3.4 Å
Structure data

PDB-7t2a:
Crystal structure of HLA-DP4 in complex with Ply
Method: X-RAY DIFFRACTION / Resolution: 3.04 Å

PDB-7t2b:
Crystal structure of the 5F TCR in complex with HLA-DP4-Ply
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-7t2c:
Crystal structure of the B5 TCR in complex with HLA-DP4-Ply
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-7t2d:
Crystal structure of the B1 TCR in complex with HLA-DP4-Ply
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • streptococcus pneumoniae (bacteria)
KeywordsIMMUNE SYSTEM / pHLA complex / TCR-pHLA complex

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