タイトル | Engineering the Substrate Specificity of a P450 Dimerase Enables the Collective Biosynthesis of Heterodimeric Tryptophan-Containing Diketopiperazines. |
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ジャーナル・号・ページ | Angew. Chem. Int. Ed. Engl., Vol. 62, Page e202304994-e202304994, Year 2023 |
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掲載日 | 2022年12月9日 (構造データの登録日) |
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著者 | Sun, C. / Ma, B.D. / Li, G. / Tian, W. / Yang, L. / Peng, H. / Lin, Z. / Deng, Z. / Kong, X.D. / Qu, X. |
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リンク | Angew. Chem. Int. Ed. Engl. / PubMed:37083030 |
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手法 | X線回折 |
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解像度 | 1.5 - 2.1 Å |
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構造データ | PDB-8hny: Crystal structure of cytochrome P450 NasF5053 mutant E73S complexed with 5FCWP 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-8hnz: Crystal structure of cytochrome P450 NasF5053 mutant E73S complexed with 6FCWP 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-8ho0: Crystal structure of cytochrome P450 NasF5053 mutant E73S complexed with 8FCWP 手法: X-RAY DIFFRACTION / 解像度: 1.71 Å PDB-8ho1: Crystal structure of cytochrome P450 NasF5053 mutant F387G 手法: X-RAY DIFFRACTION / 解像度: 2 Å |
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化合物 | ChemComp-2IV: (3~{S},8~{a}~{S})-3-[(4-fluoranyl-1~{H}-indol-3-yl)methyl]-2,3,6,7,8,8~{a}-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
ChemComp-3I5: (3~{S},8~{a}~{S})-3-[(5-fluoranyl-1~{H}-indol-3-yl)methyl]-2,3,6,7,8,8~{a}-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
ChemComp-3ZI: (3~{S},8~{a}~{S})-3-[(7-fluoranyl-1~{H}-indol-3-yl)methyl]-2,3,6,7,8,8~{a}-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
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由来 | streptomyces sp. nrrl f-5053 (バクテリア)
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キーワード | OXIDOREDUCTASE / P450 |
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