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Structure paper

TitleA tiny loop in the Argonaute PIWI domain tunes small RNA seed strength.
Journal, issue, pagesEmbo Rep., Vol. 24, Page e55806-e55806, Year 2023
Publish dateJun 6, 2022 (structure data deposition date)
AuthorsXiao, Y. / Liu, T.M. / MacRae, I.J.
External linksEmbo Rep. / PubMed:37082939
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-8d6j:
Human Ago2 bound to miR122(21nt) with PIWI loop swapped to AtAgo10 sequence
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-8d71:
Human Ago2 bound to miR122(21nt)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsRNA BINDING PROTEIN/RNA / Argonaute / RNAi / microRNA / miRNA / RNA BINDING PROTEIN-RNA complex

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