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Title | Design, Synthesis, and Biological Evaluation of Pyrimidine Dihydroquinoxalinone Derivatives as Tubulin Colchicine Site-Binding Agents That Displayed Potent Anticancer Activity Both In Vitro and In Vivo. |
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Journal, issue, pages | Acs Pharmacol Transl Sci, Vol. 6, Page 526-545, Year 2023 |
Publish date | Feb 1, 2022 (structure data deposition date) |
Authors | Pochampally, S. / Hartman, K.L. / Wang, R. / Wang, J. / Yun, M.K. / Parmar, K. / Park, H. / Meibohm, B. / White, S.W. / Li, W. / Miller, D.D. |
External links | Acs Pharmacol Transl Sci / PubMed:37082747 |
Methods | X-ray diffraction |
Resolution | 2.1 - 2.7 Å |
Structure data | PDB-7ttd: PDB-7tte: PDB-7ttf: |
Chemicals | ChemComp-GTP: ChemComp-SO4: ChemComp-GDP: ChemComp-JUL: ChemComp-MG: ChemComp-HOH: ChemComp-JVR: ChemComp-JV9: ChemComp-GOL: |
Source |
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Keywords | CELL CYCLE/INHIBITOR / MICROTUBULE INHIBITOR / COLCHICINE / CELL CYCLE / CANCER / INHIBITOR COMPLEX / CELL CYCLE-INHIBITOR complex |