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Structure paper

TitleNanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 62, Page e202219095-e202219095, Year 2023
Publish dateOct 21, 2022 (structure data deposition date)
AuthorsVan Holsbeeck, K. / Fischer, B. / Gonzalez, S. / Gadais, C. / Versees, W. / Martins, J.C. / Martin, C. / Wohlkonig, A. / Steyaert, J. / Ballet, S.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:37067463
MethodsX-ray diffraction
Resolution2.4 - 3 Å
Structure data

PDB-8be6:
Crystal structure of SOS1-HRas-peptidomimetic2
Method: X-RAY DIFFRACTION / Resolution: 2.89880249261 Å

PDB-8be7:
Crystal structure of SOS1-HRas-peptidomimetic3
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-8be8:
Crystal structure of SOS1-HRas-peptidomimetic4
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-8be9:
Crystal structure of SOS1-HRas-peptidomimetic5
Method: X-RAY DIFFRACTION / Resolution: 2.51 Å

PDB-8bea:
Crystal structure of SOS1-HRas-peptidomimetic10
Method: X-RAY DIFFRACTION / Resolution: 2.47 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-FMT:
FORMIC ACID

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsSIGNALING PROTEIN / Complex / Stabilizer

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