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Structure paper

TitleStructural and immunological differences in Plasmodium falciparum sexual stage transmission-blocking vaccines comprised of Pfs25-EPA nanoparticles.
Journal, issue, pagesNpj Vaccines, Vol. 8, Page 56-56, Year 2023
Publish dateFeb 10, 2022 (structure data deposition date)
AuthorsMacDonald, N.J. / Singh, K. / Reiter, K. / Nguyen, V. / Shimp Jr., R. / Gittis, A.G. / Chen, B. / Burkhardt, M. / Zhang, B. / Wang, Z. ...MacDonald, N.J. / Singh, K. / Reiter, K. / Nguyen, V. / Shimp Jr., R. / Gittis, A.G. / Chen, B. / Burkhardt, M. / Zhang, B. / Wang, Z. / Herrera, R. / Moler, M. / Lee, D.Y. / Orr-Gonzalez, S. / Herrod, J. / Lambert, L.E. / Rausch, K.M. / Muratova, O. / Jones, D.S. / Wu, Y. / Jin, A.J. / Garboczi, D.N. / Duffy, P.E. / Narum, D.L.
External linksNpj Vaccines / PubMed:37061547
MethodsX-ray diffraction
Resolution2.17 Å
Structure data

PDB-7txw:
Crystal structure of the complex of the malaria sexual stage protein and vaccine target Pfs25 with the Fab fragment of a transmission blocking antibody 1G2
Method: X-RAY DIFFRACTION / Resolution: 2.17 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-GOL:
GLYCEROL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-EOH:
ETHANOL

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • plasmodium falciparum 3d7 (eukaryote)
KeywordsIMMUNE SYSTEM / malaria / transmission blocking vaccine

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