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-Structure paper
Title | Structure-guided identification of novel dual-targeting estrogen receptor alpha degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 253, Page 115328-115328, Year 2023 |
Publish date | Jun 23, 2022 (structure data deposition date) |
Authors | Xin, L. / Min, J. / Hu, H. / Li, Y. / Du, C. / Xie, B. / Cheng, Y. / Deng, X. / Shen, K. / Huang, J. ...Xin, L. / Min, J. / Hu, H. / Li, Y. / Du, C. / Xie, B. / Cheng, Y. / Deng, X. / Shen, K. / Huang, J. / Chen, C.C. / Guo, R.T. / Dong, C. / Zhou, H.B. |
External links | Eur. J. Med. Chem. / PubMed:37037140 |
Methods | X-ray diffraction |
Resolution | 2.14 - 2.22 Å |
Structure data | PDB-7y8f: PDB-7y8g: |
Chemicals | ChemComp-PEG: ChemComp-IC7: ChemComp-SO4: ChemComp-HOH: ChemComp-IAT: |
Source |
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Keywords | TRANSCRIPTION/INHIBITOR / Complex / Inhibitor / Estrogen Receptor Alpha / TRANSCRIPTION-INHIBITOR complex / TRANSCRIPTION |