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TitleStructure-based engineering of a novel CD3 epsilon-targeting antibody for reduced polyreactivity.
Journal, issue, pagesMabs, Vol. 15, Page 2189974-2189974, Year 2023
Publish dateNov 3, 2022 (structure data deposition date)
AuthorsLiu, C.Y. / Ahonen, C.L. / Brown, M.E. / Zhou, L. / Welin, M. / Krauland, E.M. / Pejchal, R. / Widboom, P.F. / Battles, M.B.
External linksMabs / PubMed:36991534
MethodsX-ray diffraction
Resolution1.81 Å
Structure data

PDB-8f0l:
Crystal Structure of the Human T cell Receptor CD3(EPSILON) N-Terminal Peptide Complexed with ADI-26906 FAB
Method: X-RAY DIFFRACTION / Resolution: 1.81 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / CD3 epsilon / antibody-antigen complex / MEMBRANE PROTEIN-IMMUNE SYSTEM COMPLEX

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