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TitleStructures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies.
Journal, issue, pagesCancer Res Commun, Vol. 3, Page 175-191, Year 2023
Publish dateMar 10, 2022 (structure data deposition date)
AuthorsZhan, J. / Lin, D. / Watson, N. / Esser, L. / Tang, W.K. / Zhang, A. / Liu, X. / Hassan, R. / Gleinich, A. / Shajahan, A. ...Zhan, J. / Lin, D. / Watson, N. / Esser, L. / Tang, W.K. / Zhang, A. / Liu, X. / Hassan, R. / Gleinich, A. / Shajahan, A. / Azadi, P. / Pastan, I. / Xia, D.
External linksCancer Res Commun / PubMed:36968141
MethodsX-ray diffraction
Resolution2.09 - 3.609 Å
Structure data

PDB-7u9j:
Crystal structure of Mesothelin-207 fragment
Method: X-RAY DIFFRACTION / Resolution: 2.09 Å

PDB-7ued:
Crystal structure of full length mesothelin bound with MORAb-009 Fab
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-8cx3:
Crystal structure of full-length mesothelin
Method: X-RAY DIFFRACTION / Resolution: 3.609 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsCELL ADHESION / Mesothelin / IMMUNE SYSTEM

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