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-Structure paper
Title | Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2- b ]pyridazines as Glycogen Synthase Kinase-3 beta (GSK-3 beta ) Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 4231-4252, Year 2023 |
Publish date | Jun 30, 2022 (structure data deposition date) |
![]() | Hartz, R.A. / Ahuja, V.T. / Sivaprakasam, P. / Xiao, H. / Krause, C.M. / Clarke, W.J. / Kish, K. / Lewis, H. / Szapiel, N. / Ravirala, R. ...Hartz, R.A. / Ahuja, V.T. / Sivaprakasam, P. / Xiao, H. / Krause, C.M. / Clarke, W.J. / Kish, K. / Lewis, H. / Szapiel, N. / Ravirala, R. / Mutalik, S. / Nakmode, D. / Shah, D. / Burton, C.R. / Macor, J.E. / Dubowchik, G.M. |
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Methods | X-ray diffraction |
Resolution | 2.374 - 2.463 Å |
Structure data | ![]() PDB-8djc: ![]() PDB-8dje: |
Chemicals | ![]() ChemComp-UAU: ![]() ChemComp-HOH: ![]() ChemComp-U6S: |
Source |
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![]() | TRANSFERASE/INHIBITOR / KINASE / GSK3B / TRANSFERASE-TRANSFERASE INHIBITOR complex / TRANSFERASE / TRANSFERASE-INHIBITOR complex |