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TitleEpigenetic CpG duplex marks probed by an evolved DNA reader via a well-tempered conformational plasticity.
Journal, issue, pagesNucleic Acids Res., Vol. 51, Page 6495-6506, Year 2023
Publish dateJul 28, 2022 (structure data deposition date)
AuthorsSingh, H. / Das, C.K. / Buchmuller, B.C. / Schafer, L.V. / Summerer, D. / Linser, R.
External linksNucleic Acids Res. / PubMed:36919612
MethodsNMR (solution)
Structure data

PDB-8ajr:
The Solution Structure of the Triple Mutant Methyl-CpG-Binding Domain from MeCP2
Method: SOLUTION NMR

PDB-8alq:
The Solution Structure of the Triple Mutant Methyl-CpG-Binding Domain from MeCP2 that Binds to Asymmetrically Modified DNA
Method: SOLUTION NMR

Source
  • homo sapiens (human)
KeywordsGENE REGULATION / Epigenetic modifications / Reader protein / Domain of MeCP2 / DNA BINDING PROTEIN / hmC-mC complex / methyl-CpG-binding domain (MBD) of MeCP2

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