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| Title | New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus . |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 66, Page 3968-3994, Year 2023 |
| Publish date | Nov 12, 2022 (structure data deposition date) |
 Authors | Durcik, M. / Cotman, A.E. / Toplak, Z. / Mozina, S. / Skok, Z. / Szili, P.E. / Czikkely, M. / Maharramov, E. / Vu, T.H. / Piras, M.V. ...Durcik, M. / Cotman, A.E. / Toplak, Z. / Mozina, S. / Skok, Z. / Szili, P.E. / Czikkely, M. / Maharramov, E. / Vu, T.H. / Piras, M.V. / Zidar, N. / Ilas, J. / Zega, A. / Trontelj, J. / Pardo, L.A. / Hughes, D. / Huseby, D. / Berruga-Fernandez, T. / Cao, S. / Simoff, I. / Svensson, R. / Korol, S.V. / Jin, Z. / Vicente, F. / Ramos, M.C. / Mundy, J.E.A. / Maxwell, A. / Stevenson, C.E.M. / Lawson, D.M. / Glinghammar, B. / Sjostrom, E. / Bohlin, M. / Oreskar, J. / Alver, S. / Janssen, G.V. / Sterk, G.J. / Kikelj, D. / Pal, C. / Tomasic, T. / Peterlin Masic, L. |
 External links | J. Med. Chem. / PubMed:36877255 |
| Methods | X-ray diffraction |
| Resolution | 1.6 Å |
| Structure data |  PDB-8bn6: |
| Chemicals |  ChemComp-CA:  ChemComp-R53:  ChemComp-HOH: |
| Source |
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 Keywords | DNA BINDING PROTEIN / DNA GYRASE / GYRB / INHIBITOR / ANTIBACTERIAL / ISOMERASE |
pseudomonas aeruginosa pao1 (bacteria)