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TitleCrocodile defensin (CpoBD13) antifungal activity via pH-dependent phospholipid targeting and membrane disruption.
Journal, issue, pagesNat Commun, Vol. 14, Page 1170-1170, Year 2023
Publish dateDec 19, 2021 (structure data deposition date)
AuthorsWilliams, S.A. / Lay, F.T. / Bindra, G.K. / Banjara, S. / Poon, I.K.H. / Phan, T.K. / Kvansakul, M. / Hulett, M.D.
External linksNat Commun / PubMed:36859344
MethodsX-ray diffraction
Resolution1.45 - 1.8 Å
Structure data

PDB-7t9q:
Crystal structure of Crocodile defensin CpoBD13
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-7t9r:
Crystal structure of Crocodile defensin CpoBD13:phosphatidic acid complex
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

Chemicals

ChemComp-FLC:
CITRATE ANION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-PA6:
(R)-2-(FORMYLOXY)-3-(PHOSPHONOOXY)PROPYL PENTANOATE

ChemComp-PO4:
PHOSPHATE ION

Source
  • crocodylus porosus (Australian saltwater crocodile)
KeywordsANTIMICROBIAL PROTEIN / Defensin / phosphatidic acid / complex / phospholipid

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