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TitleA novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1.
Journal, issue, pagesCancer Cell Int, Vol. 23, Page 36-36, Year 2023
Publish dateFeb 20, 2023 (structure data deposition date)
AuthorsNumata, M. / Haginoya, N. / Shiroishi, M. / Hirata, T. / Sato-Otsubo, A. / Yoshikawa, K. / Takata, Y. / Nagase, R. / Kashimoto, Y. / Suzuki, M. ...Numata, M. / Haginoya, N. / Shiroishi, M. / Hirata, T. / Sato-Otsubo, A. / Yoshikawa, K. / Takata, Y. / Nagase, R. / Kashimoto, Y. / Suzuki, M. / Schulte, N. / Polier, G. / Kurimoto, A. / Tomoe, Y. / Toyota, A. / Yoneyama, T. / Imai, E. / Watanabe, K. / Hamada, T. / Kanada, R. / Watanabe, J. / Kagoshima, Y. / Tokumaru, E. / Murata, K. / Baba, T. / Shinozaki, T. / Ohtsuka, M. / Goto, K. / Karibe, T. / Deguchi, T. / Gocho, Y. / Yoshida, M. / Tomizawa, D. / Kato, M. / Tsutsumi, S. / Kitagawa, M. / Abe, Y.
External linksCancer Cell Int / PubMed:36841758
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-8ig0:
Crystal structure of menin in complex with DS-1594b
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-7IX:
(1R,2S,4R)-4-[[4-(5,6-dimethoxypyridazin-3-yl)phenyl]methylamino]-2-[methyl-[6-[2,2,2-tris(fluoranyl)ethyl]thieno[2,3-d]pyrimidin-4-yl]amino]cyclopentan-1-ol

ChemComp-UNX:
Unknown entry

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION/INHIBITOR / leukemia / TRANSCRIPTION-INHIBITOR COMPLEX

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