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Structure paper

TitleWatching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Journal, issue, pagesNat Commun, Vol. 14, Page 903-903, Year 2023
Publish dateFeb 18, 2022 (structure data deposition date)
AuthorsWranik, M. / Weinert, T. / Slavov, C. / Masini, T. / Furrer, A. / Gaillard, N. / Gioia, D. / Ferrarotti, M. / James, D. / Glover, H. ...Wranik, M. / Weinert, T. / Slavov, C. / Masini, T. / Furrer, A. / Gaillard, N. / Gioia, D. / Ferrarotti, M. / James, D. / Glover, H. / Carrillo, M. / Kekilli, D. / Stipp, R. / Skopintsev, P. / Brunle, S. / Muhlethaler, T. / Beale, J. / Gashi, D. / Nass, K. / Ozerov, D. / Johnson, P.J.M. / Cirelli, C. / Bacellar, C. / Braun, M. / Wang, M. / Dworkowski, F. / Milne, C. / Cavalli, A. / Wachtveitl, J. / Steinmetz, M.O. / Standfuss, J.
External linksNat Commun / PubMed:36807348
MethodsX-ray diffraction
Resolution1.8 - 2.2 Å
Structure data

PDB-7yyy:
Molecular snapshots of drug release from tubulin: 1 microsecond after photoactivation
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-7yyz:
Molecular snapshots of drug release from tubulin: 10 microseconds after photoactivation.
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-7yz0:
Molecular snapshots of drug release from tubulin: 100 microseconds after photoactivation.
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-7yz1:
Molecular snapshots of drug release from tubulin: 1 millisecond after photoactivation.
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-7yz2:
Molecular snapshots of drug release from tubulin: 10 milliseconds after photoactivation.
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-7yz3:
Molecular snapshots of drug release from tubulin: Apo state
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-7yz5:
Molecular snapshots of drug release from tubulin: 100 milliseconds (steady state)
Method: X-RAY DIFFRACTION / Resolution: 2.11 Å

PDB-7yz6:
Molecular snapshots of drug release from tubulin: Dark (steady state)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-VYT:
Azo-Combretastatin A4 (trans)

ChemComp-HOH:
WATER

ChemComp-IBL:
Azo-Combretastatin A4 (cis)

Source
  • synthetic construct (others)
  • bos taurus (domestic cattle)
KeywordsCELL CYCLE / time-resolved serial crystallography / tubulin dynamics / azobenzene dynamics

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