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TitleHighly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes.
Journal, issue, pagesImmunity, Vol. 56, Page 406-419.e7, Year 2023
Publish dateMay 5, 2022 (structure data deposition date)
AuthorsFabra-Garcia, A. / Hailemariam, S. / de Jong, R.M. / Janssen, K. / Teelen, K. / van de Vegte-Bolmer, M. / van Gemert, G.J. / Ivanochko, D. / Semesi, A. / McLeod, B. ...Fabra-Garcia, A. / Hailemariam, S. / de Jong, R.M. / Janssen, K. / Teelen, K. / van de Vegte-Bolmer, M. / van Gemert, G.J. / Ivanochko, D. / Semesi, A. / McLeod, B. / Vos, M.W. / de Bruijni, M.H.C. / Bolscher, J.M. / Szabat, M. / Vogt, S. / Kraft, L. / Duncan, S. / Kamya, M.R. / Feeney, M.E. / Jagannathan, P. / Greenhouse, B. / Dechering, K.J. / Sauerwein, R.W. / King, C.R. / MacGill, R.S. / Bousema, T. / Julien, J.P. / Jore, M.M.
External linksImmunity / PubMed:36792574
MethodsX-ray diffraction
Resolution2.86 Å
Structure data

PDB-7uxl:
Crystal structure of malaria transmission-blocking antigen Pfs48/45-6C variant in complex with human antibodies RUPA-44 and RUPA-29
Method: X-RAY DIFFRACTION / Resolution: 2.86 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • plasmodium falciparum (malaria parasite P. falciparum)
KeywordsIMMUNE SYSTEM / Pfs48/45 / human transmission-blocking antibodies / Plasmodium falciparum / Malaria

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