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| Title | Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 66, Page 2918-2945, Year 2023 |
| Publish date | Jan 21, 2022 (structure data deposition date) |
 Authors | Scott, J.S. / Stead, D. / Barlaam, B. / Breed, J. / Carbajo, R.J. / Chiarparin, E. / Cureton, N. / Davey, P.R.J. / Fisher, D.I. / Gangl, E.T. ...Scott, J.S. / Stead, D. / Barlaam, B. / Breed, J. / Carbajo, R.J. / Chiarparin, E. / Cureton, N. / Davey, P.R.J. / Fisher, D.I. / Gangl, E.T. / Grebe, T. / Greenwood, R.D. / Hande, S. / Hatoum-Mokdad, H. / Hughes, S.J. / Hunt, T.A. / Johnson, T. / Kavanagh, S.L. / Klinowska, T.C.M. / Larner, C.J.B. / Lawson, M. / Lister, A.S. / Longmire, D. / Marden, S. / McGuire, T.M. / McMillan, C. / McMurray, L. / Morrow, C.J. / Nissink, J.W.M. / Moss, T.A. / O'Donovan, D.H. / Polanski, R. / Stokes, S. / Thakur, K. / Trueman, D. / Truman, C. / Tucker, M.J. / Wang, H. / Whalley, N. / Wu, D. / Wu, Y. / Yang, B. / Yang, W. |
 External links | J. Med. Chem. / PubMed:36727211 |
| Methods | X-ray diffraction |
| Resolution | 1.68 - 1.9 Å |
| Structure data |  PDB-7qvj:  PDB-7qvl: |
| Chemicals |  ChemComp-H09:  ChemComp-HOH:  ChemComp-GZI: |
| Source |
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 Keywords | TRANSCRIPTION / Ligand-binding domain of oestrogen nuclear hormone receptor / GENE REGULATION / OESTROGEN RECEPTOR |
homo sapiens (human)