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TitlePeptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization.
Journal, issue, pagesStructure, Vol. 31, Page 265-281.e7, Year 2023
Publish dateMay 24, 2022 (structure data deposition date)
AuthorsAguilar, F. / Yu, S. / Grant, R.A. / Swanson, S. / Ghose, D. / Su, B.G. / Sarosiek, K.A. / Keating, A.E.
External linksStructure / PubMed:36706751
MethodsX-ray diffraction
Resolution1.3 - 1.99 Å
Structure data

PDB-8czf:
Human BAK in complex with the dF2 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

PDB-8czg:
Human BAK in complex with the dF3 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

PDB-8czh:
Human BAK in complex with the dM2 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsAPOPTOSIS / BAK / activator / Bcl-2 family / inhibitor

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