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Structure paper

TitlePeptide transporter structure reveals binding and action mechanism of a potent PEPT1 and PEPT2 inhibitor.
Journal, issue, pagesCommun Chem, Vol. 5, Page 23-23, Year 2022
Publish dateOct 15, 2021 (structure data deposition date)
AuthorsStauffer, M. / Jeckelmann, J.M. / Ilgu, H. / Ucurum, Z. / Boggavarapu, R. / Fotiadis, D.
External linksCommun Chem / PubMed:36697632
MethodsX-ray diffraction
Resolution2.54 - 2.71 Å
Structure data

PDB-7q0l:
Crystal structure of the peptide transporter YePEPT-K314A at 2.93 A
Method: X-RAY DIFFRACTION / Resolution: 2.71 Å

PDB-7q0m:
Crystal structure of the peptide transporter YePEPT-K314A in complex with LZNV at 2.66 A
Method: X-RAY DIFFRACTION / Resolution: 2.54 Å

Chemicals

ChemComp-OPK:
(2~{S})-2-[[(2~{S})-2-azanyl-6-[(4-nitrophenyl)methoxycarbonylamino]hexanoyl]amino]-3-methyl-butanoic acid

ChemComp-UMQ:
UNDECYL-MALTOSIDE / detergent*YM

Source
  • yersinia enterocolitica subsp. palearctica ye-p4 (bacteria)
KeywordsMEMBRANE PROTEIN / MFS / peptide transporter / solute transporter / Inhibitor bound / LZNV / PEPT1

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