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Structure paper

TitleA 2.8 angstrom Structure of Zoliflodacin in a DNA Cleavage Complex with Staphylococcus aureus DNA Gyrase.
Journal, issue, pagesInt J Mol Sci, Vol. 24, Year 2023
Publish dateNov 15, 2022 (structure data deposition date)
AuthorsMorgan, H. / Lipka-Lloyd, M. / Warren, A.J. / Hughes, N. / Holmes, J. / Burton, N.P. / Mahenthiralingam, E. / Bax, B.D.
External linksInt J Mol Sci / PubMed:36675148
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-8bp2:
2.8A STRUCTURE OF ZOLIFLODACIN WITH S.AUREUS DNA GYRASE AND DNA
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-MN:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-BTB:
2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-R8U:
Zoliflodacin

ChemComp-HOH:
WATER

Source
  • staphylococcus aureus (bacteria)
  • synthetic construct (others)
KeywordsISOMERASE / TYPE IIA TOPOISOMERASE / ANTIBACTERIAL / INHIBITOR

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