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TitleComplexed Crystal Structure of the Dihydroorotase Domain of Human CAD Protein with the Anticancer Drug 5-Fluorouracil.
Journal, issue, pagesBiomolecules, Vol. 13, Year 2023
Publish dateSep 16, 2022 (structure data deposition date)
AuthorsLin, E.S. / Huang, Y.H. / Yang, P.C. / Peng, W.F. / Huang, C.Y.
External linksBiomolecules / PubMed:36671534
MethodsX-ray diffraction
Resolution1.64 - 1.97 Å
Structure data

PDB-8gvz:
Crystal structure of the human dihydroorotase domain in complex with the anticancer drug 5-fluorouracil
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

PDB-8gw0:
Crystal structure of the human dihydroorotase domain in complex with malic acid
Method: X-RAY DIFFRACTION / Resolution: 1.64 Å

Chemicals

ChemComp-URF:
5-FLUOROURACIL / medication, chemotherapy*YM

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-LMR:
(2S)-2-hydroxybutanedioic acid

Source
  • homo sapiens (human)
KeywordsHYDROLASE / dihydroorotase / Human CAD / ZN

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