EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs.
ジャーナル・号・ページ	Biochemistry, Vol. 62, Page 710-721, Year 2023
掲載日	2022年11月10日 (構造データの登録日)
著者	Pang, A.H. / Green, K.D. / Punetha, A. / Thamban Chandrika, N. / Howard, K.C. / Garneau-Tsodikova, S. / Tsodikov, O.V.
リンク	Biochemistry / PubMed:36657084
手法	X線回折
解像度	1.91 - 2.42 Å
構造データ	PDB-8f4a: Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with chlorhexidine 手法: X-RAY DIFFRACTION / 解像度: 2.41 Å PDB-8f4t: Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with proguanil 手法: X-RAY DIFFRACTION / 解像度: 1.93 Å PDB-8f4u: Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with azelastine 手法: X-RAY DIFFRACTION / 解像度: 1.91 Å PDB-8f4w: Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with venlafaxine 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-8f4z: Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with chloroquine 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-8f51: Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with mefloquine 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å PDB-8f55: Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis H37Rv in complex with inhibitor SGT1614 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-8f57: Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with inhibitor SGT1615 手法: X-RAY DIFFRACTION / 解像度: 2.42 Å PDB-8f58: Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with inhibitor SGT1616 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å
化合物	ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-XC9: 1-[6-[azanylidene-[[azanylidene-[[(4-chlorophenyl)amino]methyl]-$l^{4}-azanyl]methyl]-$l^{4}-azanyl]hexyl]-3-[~{N}-(4-chlorophenyl)carbamimidoyl]guanidine / クロルヘキシジン ChemComp-HOH: WATER ChemComp-XEW: N-(4-chlorophenyl)-N'-(propan-2-yl)triimidodicarbonic diamide / プログアニル ChemComp-PEG: DI(HYDROXYETHYL)ETHER / ジエチレングリコ-ル ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-XG0: 4-[(4-chlorophenyl)methyl]-2-[(4S)-1-methylazepan-4-yl]phthalazin-1(2H)-one / 4-(p-クロロベンジル)-2-[(1-メチルヘキサヒドロ-1H-アゼピン)-4β-イル]フタラジン-1(2H)-オン ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-VFX: 1-[(1R)-2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol / (R)-ベンラファキシン ChemComp-CLQ: N4-(7-CHLORO-QUINOLIN-4-YL)-N1,N1-DIETHYL-PENTANE-1,4-DIAMINE / (R)-クロロキン / 薬剤YM ChemComp-YMZ: Mefloquine / (+)-メフロキン / 薬剤YM ChemComp-XF2: (2E)-2-[(4-chlorophenyl)methylidene]hydrazine-1-carboximidamide / 1-(4-クロロベンジリデンアミノ)グアニジン ChemComp-XEL: (1E)-1-[(4-chlorophenyl)methylidene]-2-(3-fluorophenyl)hydrazine ChemComp-XEH*: (1E)-1-[(4-chlorophenyl)methylidene]-2-(4-fluorophenyl)hydrazine
由来	mycobacterium tuberculosis h37rv (結核菌)
キーワード	TRANSFERASE/TRANSFERASE INHIBITOR / drug resistance / inhibitor / acetylation / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex / histone / inhibition / aminoglycoside