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Structure paper

TitleThe SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators.
Journal, issue, pagesNat Commun, Vol. 14, Page 166-166, Year 2023
Publish dateFeb 24, 2022 (structure data deposition date)
AuthorsAppel, L.M. / Franke, V. / Benedum, J. / Grishkovskaya, I. / Strobl, X. / Polyansky, A. / Ammann, G. / Platzer, S. / Neudolt, A. / Wunder, A. ...Appel, L.M. / Franke, V. / Benedum, J. / Grishkovskaya, I. / Strobl, X. / Polyansky, A. / Ammann, G. / Platzer, S. / Neudolt, A. / Wunder, A. / Walch, L. / Kaiser, S. / Zagrovic, B. / Djinovic-Carugo, K. / Akalin, A. / Slade, D.
External linksNat Commun / PubMed:36631525
MethodsX-ray diffraction
Resolution1.45 - 1.55 Å
Structure data

PDB-7z1k:
Crystal structure of the SPOC domain of human SHARP (SPEN) in complex with RNA polymerase II CTD heptapeptide phosphorylated on Ser5
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-7z27:
Crystal structure of the SPOC domain of human RBM15
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / human SHARP / SPOC domain / RNA polymerase II CTD heptapeptide / Rbm15

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