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TitleDiscovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia.
Journal, issue, pagesJ. Med. Chem., Vol. 66, Page 1157-1171, Year 2023
Publish dateJun 28, 2022 (structure data deposition date)
AuthorsLayton, M.E. / Kern, J.C. / Hartingh, T.J. / Shipe, W.D. / Raheem, I. / Kandebo, M. / Hayes, R.P. / Huszar, S. / Eddins, D. / Ma, B. ...Layton, M.E. / Kern, J.C. / Hartingh, T.J. / Shipe, W.D. / Raheem, I. / Kandebo, M. / Hayes, R.P. / Huszar, S. / Eddins, D. / Ma, B. / Fuerst, J. / Wollenberg, G.K. / Li, J. / Fritzen, J. / McGaughey, G.B. / Uslaner, J.M. / Smith, S.M. / Coleman, P.J. / Cox, C.D.
External linksJ. Med. Chem. / PubMed:36624931
MethodsX-ray diffraction
Resolution2.016 Å
Structure data

PDB-8di4:
Discovery of MK-8189, a highly potent and selective PDE10A inhibitor for the treatment of schizophrenia
Method: X-RAY DIFFRACTION / Resolution: 2.016 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-S9I:
2-methyl-6-{[(1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl]methoxy}-N-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]pyrimidin-4-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / PDE10A / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complex

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