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-Structure paper
Title | Discovery of a Novel ATP-Competitive MEK Inhibitor DS03090629 that Overcomes Resistance Conferred by BRAF Overexpression in BRAF-Mutated Melanoma. |
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Journal, issue, pages | Mol. Cancer Ther., Vol. 22, Page 317-332, Year 2023 |
Publish date | Apr 22, 2022 (structure data deposition date) |
Authors | Takano, K. / Munehira, Y. / Hatanaka, M. / Murakami, R. / Shibata, Y. / Shida, T. / Takeuchi, K. / Takechi, S. / Tabata, T. / Shimada, T. ...Takano, K. / Munehira, Y. / Hatanaka, M. / Murakami, R. / Shibata, Y. / Shida, T. / Takeuchi, K. / Takechi, S. / Tabata, T. / Shimada, T. / Kishikawa, S. / Matsui, Y. / Ubukata, O. / Seki, T. / Kaneta, Y. |
External links | Mol. Cancer Ther. / PubMed:36622773 |
Methods | X-ray diffraction |
Resolution | 2.1 Å |
Structure data | PDB-7xlp: PDB-7xnc: |
Chemicals | ChemComp-FZC: ChemComp-DMS: ChemComp-CA: ChemComp-HOH: ChemComp-GIK: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Kinase / Inhibitor / Complex / ATP competitive / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex |