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TitleDiscovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction.
Journal, issue, pagesAcs Chem. Biol., Vol. 18, Page 34-40, Year 2023
Publish dateNov 5, 2022 (structure data deposition date)
AuthorsDing, J. / Li, G. / Liu, H. / Liu, L. / Lin, Y. / Gao, J. / Zhou, G. / Shen, L. / Zhao, M. / Yu, Y. ...Ding, J. / Li, G. / Liu, H. / Liu, L. / Lin, Y. / Gao, J. / Zhou, G. / Shen, L. / Zhao, M. / Yu, Y. / Guo, W. / Hommel, U. / Ottl, J. / Blank, J. / Aubin, N. / Wei, Y. / He, H. / Sage, D.R. / Atadja, P.W. / Li, E. / Jain, R.K. / Tallarico, J.A. / Canham, S.M. / Chiang, Y.L. / Wang, H.
External linksAcs Chem. Biol. / PubMed:36594833
MethodsX-ray diffraction
Resolution2.14 Å
Structure data

PDB-8f1g:
Crystal structure of human WDR5 in complex with compound WM662
Method: X-RAY DIFFRACTION / Resolution: 2.14 Å

Chemicals

ChemComp-X8N:
(2S)-2-({(2S)-3-(3'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-1-[(1H-tetrazol-5-yl)amino]propan-2-yl}oxy)propanoic acid

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / WDR5 / WM662 / Myc

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