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Structure paper

TitleComputational design of constitutively active cGAS.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 30, Page 72-80, Year 2023
Publish dateDec 4, 2020 (structure data deposition date)
AuthorsDowling, Q.M. / Volkman, H.E. / Gray, E.E. / Ovchinnikov, S. / Cambier, S. / Bera, A.K. / Sankaran, B. / Johnson, M.R. / Bick, M.J. / Kang, A. ...Dowling, Q.M. / Volkman, H.E. / Gray, E.E. / Ovchinnikov, S. / Cambier, S. / Bera, A.K. / Sankaran, B. / Johnson, M.R. / Bick, M.J. / Kang, A. / Stetson, D.B. / King, N.P.
External linksNat. Struct. Mol. Biol. / PubMed:36593311
MethodsX-ray diffraction
Resolution2.18 - 2.6 Å
Structure data

PDB-7kxs:
Computational design of constitutively active cGAS
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-7lz3:
Computational design of constitutively active cGAS
Method: X-RAY DIFFRACTION / Resolution: 2.18 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • mus musculus (house mouse)
  • synthetic construct (others)
KeywordsDE NOVO PROTEIN / DE NOVO DESIGNED / constitutive mutant / cGAS

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