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TitleDiscovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor.
Journal, issue, pagesJ. Med. Chem., Vol. 66, Page 695-715, Year 2023
Publish dateSep 26, 2022 (structure data deposition date)
AuthorsKanada, R. / Kagoshima, Y. / Suzuki, T. / Nakamura, A. / Funami, H. / Watanabe, J. / Asano, M. / Takahashi, M. / Ubukata, O. / Suzuki, K. ...Kanada, R. / Kagoshima, Y. / Suzuki, T. / Nakamura, A. / Funami, H. / Watanabe, J. / Asano, M. / Takahashi, M. / Ubukata, O. / Suzuki, K. / Aikawa, T. / Sato, K. / Goto, M. / Setsu, G. / Ito, K. / Kihara, K. / Kuroha, M. / Kohno, T. / Ogiwara, H. / Isoyama, T. / Tominaga, Y. / Higuchi, S. / Naito, H.
External linksJ. Med. Chem. / PubMed:36572866
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-8gzc:
Crystal structure of EP300 HAT domain in complex with compound 10
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-KQO:
(2~{R},4~{R})-4-fluoranyl-1-[1-(4-methoxyphenyl)cyclohexyl]carbonyl-~{N}-(1~{H}-pyrazolo[4,3-b]pyridin-5-yl)pyrrolidine-2-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / epigenetics / SBDD / Histone acetyltransferase

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