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Structure paper

TitleStructure and function analysis of Sam68 and hnRNP A1 synergy in the exclusion of exon 7 from SMN2 transcripts.
Journal, issue, pagesProtein Sci., Vol. 32, Page e4553-e4553, Year 2023
Publish dateMar 16, 2022 (structure data deposition date)
AuthorsNadal, M. / Anton, R. / Dorca-Arevalo, J. / Estebanez-Perpina, E. / Tizzano, E.F. / Fuentes-Prior, P.
External linksProtein Sci. / PubMed:36560896
MethodsX-ray diffraction
Resolution2.06 - 3.333 Å
Structure data

PDB-7z89:
Sam68
Method: X-RAY DIFFRACTION / Resolution: 2.76 Å

PDB-7z8a:
Sam68
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

PDB-7z9a:
Sam68
Method: X-RAY DIFFRACTION / Resolution: 2.57 Å

PDB-7z9b:
Sam68
Method: X-RAY DIFFRACTION / Resolution: 3.333 Å

PDB-7zab:
Sam68
Method: X-RAY DIFFRACTION / Resolution: 2.46 Å

PDB-7zac:
Sam68
Method: X-RAY DIFFRACTION / Resolution: 2.08 Å

PDB-7zaf:
Sam68
Method: X-RAY DIFFRACTION / Resolution: 2.71 Å

PDB-7zam:
Sam68
Method: X-RAY DIFFRACTION / Resolution: 2.79 Å

Chemicals

ChemComp-IOD:
IODIDE ION

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-NO3:
NITRATE ION

ChemComp-LI:
Unknown entry

ChemComp-PGO:
S-1,2-PROPANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

Source
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN / Spinal muscular Atrophy / STAR / Spinal Muscular Atrophy (SMA)

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