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Title | Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity. |
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Journal, issue, pages | J. Biol. Chem., Vol. 299, Page 102800-102800, Year 2022 |
Publish date | Jun 27, 2022 (structure data deposition date) |
Authors | Cellupica, E. / Caprini, G. / Cordella, P. / Cukier, C. / Fossati, G. / Marchini, M. / Rocchio, I. / Sandrone, G. / Vanoni, M.A. / Vergani, B. ...Cellupica, E. / Caprini, G. / Cordella, P. / Cukier, C. / Fossati, G. / Marchini, M. / Rocchio, I. / Sandrone, G. / Vanoni, M.A. / Vergani, B. / Zrubek, K. / Stevenazzi, A. / Steinkuhler, C. |
External links | J. Biol. Chem. / PubMed:36528061 |
Methods | X-ray diffraction |
Resolution | 1.6 Å |
Structure data | PDB-8a8z: |
Chemicals | ChemComp-LDL: ChemComp-ZN: ChemComp-K: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / HISTONE DEACETYLASE / COMPLEX WITH HYDRAZIDE / NON-HYDROXAMATE ZINC BINDING GROUP / MECHANISM-BASED INHIBITOR |