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Structure paper

TitleStructural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 13, Page 1856-1863, Year 2022
Publish dateApr 2, 2022 (structure data deposition date)
AuthorsHeppner, D.E. / Wittlinger, F. / Beyett, T.S. / Shaurova, T. / Urul, D.A. / Buckley, B. / Pham, C.D. / Schaeffner, I.K. / Yang, B. / Ogboo, B.C. ...Heppner, D.E. / Wittlinger, F. / Beyett, T.S. / Shaurova, T. / Urul, D.A. / Buckley, B. / Pham, C.D. / Schaeffner, I.K. / Yang, B. / Ogboo, B.C. / May, E.W. / Schaefer, E.M. / Eck, M.J. / Laufer, S.A. / Hershberger, P.A.
External linksAcs Med. Chem. Lett. / PubMed:36518696
MethodsX-ray diffraction
Resolution2.4 - 2.6 Å
Structure data

PDB-7ukv:
Wild type EGFR in complex with Lazertinib (YH25448)
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-7ukw:
EGFR(T790M/V948R) in complex with Lazertinib (YH25448)
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-ZRT:
N-[5-{[(4P)-4-{4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl}pyrimidin-2-yl]amino}-4-methoxy-2-(morpholin-4-yl)phenyl]propanamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/INHIBITOR / Cancer / Drug Discovery / Kinase / TRANSFERASE / TRANSFERASE-INHIBITOR complex / Drug Design / EGFR / Signal Transduction / Targeted Therapy

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