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TitleDual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis.
Journal, issue, pagesSci Transl Med, Vol. 14, Page eabp9159-eabp9159, Year 2022
Publish dateMar 2, 2022 (structure data deposition date)
AuthorsChavarria-Smith, J. / Chiu, C.P.C. / Jackman, J.K. / Yin, J. / Zhang, J. / Hackney, J.A. / Lin, W.Y. / Tyagi, T. / Sun, Y. / Tao, J. ...Chavarria-Smith, J. / Chiu, C.P.C. / Jackman, J.K. / Yin, J. / Zhang, J. / Hackney, J.A. / Lin, W.Y. / Tyagi, T. / Sun, Y. / Tao, J. / Dunlap, D. / Morton, W.D. / Ghodge, S.V. / Maun, H.R. / Li, H. / Hernandez-Barry, H. / Loyet, K.M. / Chen, E. / Liu, J. / Tam, C. / Yaspan, B.L. / Cai, H. / Balazs, M. / Arron, J.R. / Li, J. / Wittwer, A.J. / Pappu, R. / Austin, C.D. / Lee, W.P. / Lazarus, R.A. / Sudhamsu, J. / Koerber, J.T. / Yi, T.
External linksSci Transl Med / PubMed:36516271
MethodsX-ray diffraction
Resolution2.371 Å
Structure data

PDB-7u5b:
Structure of Human KLK5 bound to anti-KLK5 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.371 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsHYDROLASE/IMMUNE SYSTEM / Protease / Kallikrien / KLK5 / HYDROLASE / HYDROLASE-IMMUNE SYSTEM complex

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