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Title | Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 16372-16391, Year 2022 |
Publish date | Jul 14, 2022 (structure data deposition date) |
![]() | Lin, S. / Du, T. / Zhang, J. / Wu, D. / Tian, H. / Zhang, K. / Jiang, L. / Lu, D. / Sheng, L. / Li, Y. ...Lin, S. / Du, T. / Zhang, J. / Wu, D. / Tian, H. / Zhang, K. / Jiang, L. / Lu, D. / Sheng, L. / Li, Y. / Ji, M. / Chen, X. / Xu, H. |
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Methods | X-ray diffraction |
Resolution | 2.6 Å |
Structure data | ![]() PDB-7yhn: |
Chemicals | ![]() ChemComp-GTP: ![]() ChemComp-MG: ![]() ChemComp-GDP: ![]() ChemComp-MES: ![]() ChemComp-IUK: ![]() ChemComp-HOH: |
Source |
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![]() | STRUCTURAL PROTEIN / MITOSIS / ANTITUMOR PROTEIN |