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-Structure paper
Title | Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth. |
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Journal, issue, pages | Elife, Vol. 11, Year 2022 |
Publish date | Dec 16, 2013 (structure data deposition date) |
![]() | Costantino, L. / Ferrari, S. / Santucci, M. / Salo-Ahen, O.M.H. / Carosati, E. / Franchini, S. / Lauriola, A. / Pozzi, C. / Trande, M. / Gozzi, G. ...Costantino, L. / Ferrari, S. / Santucci, M. / Salo-Ahen, O.M.H. / Carosati, E. / Franchini, S. / Lauriola, A. / Pozzi, C. / Trande, M. / Gozzi, G. / Saxena, P. / Cannazza, G. / Losi, L. / Cardinale, D. / Venturelli, A. / Quotadamo, A. / Linciano, P. / Tagliazucchi, L. / Moschella, M.G. / Guerrini, R. / Pacifico, S. / Luciani, R. / Genovese, F. / Henrich, S. / Alboni, S. / Santarem, N. / da Silva Cordeiro, A. / Giovannetti, E. / Peters, G.J. / Pinton, P. / Rimessi, A. / Cruciani, G. / Stroud, R.M. / Wade, R.C. / Mangani, S. / Marverti, G. / D'Arca, D. / Ponterini, G. / Costi, M.P. |
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Methods | X-ray diffraction |
Resolution | 2.26 - 2.32 Å |
Structure data | ![]() PDB-4o1u: ![]() PDB-4o1x: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-EDO: ![]() ChemComp-CL: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / Dimer-dimer interface modification / inactive conformation / Methyltransferase / Nucleotide biosynthesis / active conformation |