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| Title | Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 65, Page 16290-16312, Year 2022 |
| Publish date | Jun 20, 2022 (structure data deposition date) |
 Authors | Craig 2nd, R.A. / Fox, B.M. / Hu, C. / Lexa, K.W. / Osipov, M. / Thottumkara, A.P. / Larhammar, M. / Miyamoto, T. / Rana, A. / Kane, L.A. ...Craig 2nd, R.A. / Fox, B.M. / Hu, C. / Lexa, K.W. / Osipov, M. / Thottumkara, A.P. / Larhammar, M. / Miyamoto, T. / Rana, A. / Kane, L.A. / Yulyaningsih, E. / Solanoy, H. / Nguyen, H. / Chau, R. / Earr, T. / Kajiwara, Y. / Fleck, D. / Lucas, A. / Haddick, P.C.G. / Takahashi, R.H. / Tong, V. / Wang, J. / Canet, M.J. / Poda, S.B. / Scearce-Levie, K. / Srivastava, A. / Sweeney, Z.K. / Xu, M. / Zhang, R. / He, J. / Lei, Y. / Zhuo, Z. / de Vicente, J. |
 External links | J. Med. Chem. / PubMed:36469401 |
| Methods | X-ray diffraction |
| Resolution | 2.79 Å |
| Structure data |  PDB-8deg: |
| Chemicals |  ChemComp-SIQ:  ChemComp-HOH: |
| Source |
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 Keywords | SIGNALING PROTEIN / TRANSFERASE/INHIBITOR / DLK / kinase / inhibitor / TRANSFERASE-INHIBITOR complex |
homo sapiens (human)