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Structure paper

TitleDHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 119, Page e2216712119-e2216712119, Year 2022
Publish dateSep 17, 2022 (structure data deposition date)
AuthorsZhang, J. / Huang, J. / Xu, K. / Xing, P. / Huang, Y. / Liu, Z. / Tong, L. / Manley, J.L.
External linksProc. Natl. Acad. Sci. USA / PubMed:36459648
MethodsX-ray diffraction
Resolution1.8 - 2.81 Å
Structure data

PDB-8ejm:
Crystal structure of human DEAH-box helicase DHX15 in complex with SUGP1 G-patch
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8gxl:
HUMAN SUGP1 433-577
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-8gxm:
HUMAN SUGP1 433-586
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-GOL:
GLYCEROL

ChemComp-MG:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN / HYDROLASE / Complex / helicase / splicing factor / pre-mRNA splicing / pre-mRNA splicing.

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