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-Structure paper
Title | Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 80, Page 129084-129084, Year 2022 |
Publish date | Dec 10, 2021 (structure data deposition date) |
![]() | Huang, W.S. / Li, F. / Gong, Y. / Zhang, Y. / Youngsaye, W. / Xu, Y. / Zhu, X. / Greenfield, M.T. / Kohlmann, A. / Taslimi, P.M. ...Huang, W.S. / Li, F. / Gong, Y. / Zhang, Y. / Youngsaye, W. / Xu, Y. / Zhu, X. / Greenfield, M.T. / Kohlmann, A. / Taslimi, P.M. / Toms, A. / Zech, S.G. / Zhou, T. / Das, B. / Jang, H.G. / Tugnait, M. / Ye, Y.E. / Gonzalvez, F. / Baker, T.E. / Nadworny, S. / Ning, Y. / Wardwell, S.D. / Zhang, S. / Gould, A.E. / Hu, Y. / Lane, W. / Skene, R.J. / Zou, H. / Clackson, T. / Narasimhan, N.I. / Rivera, V.M. / Dalgarno, D.C. / Shakespeare, W.C. |
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Methods | X-ray diffraction |
Resolution | 2.2 - 2.61 Å |
Structure data | ![]() PDB-7t4i: ![]() PDB-7t4j: |
Chemicals | ![]() ChemComp-R28: ![]() ChemComp-HOH: ![]() ChemComp-EDO: ![]() ChemComp-CIT: |
Source |
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![]() | HYDROLASE / Kinase / Inhibitor / Complex / covalent / HYDROLASE/HYDROLASE Inhibitor / HYDROLASE-HYDROLASE Inhibitor complex |