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TitleDiscovery of a new class of reversible TEA-domain transcription factor inhibitors with a novel binding mode.
Journal, issue, pagesElife, Vol. 11, Year 2022
Publish dateMay 17, 2022 (structure data deposition date)
AuthorsHu, L. / Sun, Y. / Liu, S. / Erb, H. / Singh, A. / Mao, J. / Luo, X. / Wu, X.
External linksElife / PubMed:36398861
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-8cuh:
Crystal structure of human TEAD2 complexed with its inhibitor TM2.
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-P0I:
4-[3-(2-cyclohexylethoxy)benzoyl]-N-phenylpiperazine-1-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Transcription factor / transcription-transcription inhibitor complex

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