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TitleStable binding to phosphatidylserine-containing membranes requires conserved arginine residues in tandem C domains of blood coagulation factor VIII.
Journal, issue, pagesFront Mol Biosci, Vol. 9, Page 1040106-1040106, Year 2022
Publish dateAug 30, 2021 (structure data deposition date)
AuthorsPeters, S.C. / Childers, K.C. / Mitchell, C.E. / Avery, N.G. / Reese Jr., S.S. / Mitchell, C. / Wo, S.W. / Swanson, C.D. / Brison, C.M. / Spiegel Jr., P.C.
External linksFront Mol Biosci / PubMed:36387287
MethodsX-ray diffraction
Resolution1.3 Å
Structure data

PDB-7s0p:
Crystal structure of Porcine Factor VIII C2 Domain Bound to Phosphatidylserine
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

Chemicals

ChemComp-SEP:
PHOSPHOSERINE

ChemComp-HOH:
WATER

Source
  • sus scrofa (pig)
KeywordsLIPID BINDING PROTEIN / factor VIII / lipid / hemostasis

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