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Structure paper

TitleIdentification and structural basis of C-terminal cyclic imides as natural degrons for cereblon.
Journal, issue, pagesBiochem. Biophys. Res. Commun., Vol. 637, Page 66-72, Year 2022
Publish dateOct 15, 2022 (structure data deposition date)
AuthorsHeim, C. / Spring, A.K. / Kirchgassner, S. / Schwarzer, D. / Hartmann, M.D.
External linksBiochem. Biophys. Res. Commun. / PubMed:36375252
MethodsX-ray diffraction
Resolution1.719 - 1.72 Å
Structure data

PDB-8bc6:
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex an aspartimide degron peptide
Method: X-RAY DIFFRACTION / Resolution: 1.72 Å

PDB-8bc7:
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex an aminoglutarimide degron peptide
Method: X-RAY DIFFRACTION / Resolution: 1.719 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-EF2:
S-Thalidomide / medication*YM

Source
  • magnetospirillum gryphiswaldense (magnetotactic)
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Protein Damage / Protein Ageing / Protein Chain Break / Aspartimide / Aminoglutarimide

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