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-Structure paper
Title | NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts. |
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Journal, issue, pages | Blood, Vol. 141, Page 1584-1596, Year 2023 |
Publish date | Sep 16, 2022 (structure data deposition date) |
![]() | Zhang, D. / Harris, H.M. / Chen, J. / Judy, J. / James, G. / Kelly, A. / McIntosh, J. / Tenn-McClellan, A. / Ambing, E. / Tan, Y.S. ...Zhang, D. / Harris, H.M. / Chen, J. / Judy, J. / James, G. / Kelly, A. / McIntosh, J. / Tenn-McClellan, A. / Ambing, E. / Tan, Y.S. / Lu, H. / Gajewski, S. / Clifton, M.C. / Yung, S. / Robbins, D.W. / Pirooznia, M. / Skanland, S.S. / Gaglione, E. / Mhibik, M. / Underbayev, C. / Ahn, I.E. / Sun, C. / Herman, S.E.M. / Noviski, M. / Wiestner, A. |
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Methods | X-ray diffraction |
Resolution | 1.58 Å |
Structure data | ![]() PDB-8ejb: |
Chemicals | ![]() ChemComp-WKC: ![]() ChemComp-EDO: ![]() ChemComp-PD: ![]() ChemComp-CL: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / protein degradation / leukemia |