Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment.
Journal, issue, pages	J. Med. Chem., Vol. 65, Page 15140-15164, Year 2022
Publish date	Jun 16, 2022 (structure data deposition date)
Authors	Wang, C. / Li, J. / Qu, L. / Tang, X. / Song, X. / Yang, F. / Chen, X. / Lin, Q. / Lin, W. / Zhou, Y. ...Wang, C. / Li, J. / Qu, L. / Tang, X. / Song, X. / Yang, F. / Chen, X. / Lin, Q. / Lin, W. / Zhou, Y. / Tu, Z. / Chen, Y. / Zhang, Z. / Lu, X.
External links	J. Med. Chem. / PubMed:36355693
Methods	X-ray diffraction
Resolution	2.16 - 2.71 Å
Structure data	PDB-7y4t: Crystal structure of cMET kinase domain bound by compound 9I Method: X-RAY DIFFRACTION / Resolution: 2.16 Å PDB-7y4u: Crystal structure of cMET kinase domain bound by compound 9Y Method: X-RAY DIFFRACTION / Resolution: 2.26 Å PDB-8gvj: Crystal structure of cMET kinase domain bound by D6808 Method: X-RAY DIFFRACTION / Resolution: 2.71 Å
Chemicals	ChemComp-I90: 2-[2-[3-(1-methylpyrazol-4-yl)quinolin-6-yl]ethyl]-6-(3-nitrophenyl)pyridazin-3-one ChemComp-HOH: WATER ChemComp-I94: ~{N}-methyl-4-[1-[2-[3-(1-methylpyrazol-4-yl)quinolin-6-yl]ethyl]-6-oxidanylidene-pyridazin-3-yl]-2-(trifluoromethyl)benzamide ChemComp-KGL: (1^4Z,5^2E)-6^3-(trifluoromethyl)-5^1,5^6-dihydro-1^1H-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-5^6,7-dione
Source	homo sapiens (human)
Keywords	TRANSFERASE/INHIBITOR / TRANSFERASE INHIBITOR / TRANSFERASE / TRANSFERASE-INHIBITOR complex / Inhibitor