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TitleEnzymatic Pyridine Aromatization during Thiopeptide Biosynthesis.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 144, Page 21116-21124, Year 2022
Publish dateSep 19, 2022 (structure data deposition date)
AuthorsRice, A.J. / Pelton, J.M. / Kramer, N.J. / Catlin, D.S. / Nair, S.K. / Pogorelov, T.V. / Mitchell, D.A. / Bowers, A.A.
External linksJ. Am. Chem. Soc. / PubMed:36351243
MethodsX-ray diffraction
Resolution1.7 - 2.47 Å
Structure data

PDB-8ejy:
[4+2] Aza-Cyclase F293A variant
Method: X-RAY DIFFRACTION / Resolution: 2.47 Å

PDB-8ejz:
[4+2] Aza-Cyclase Y293F variant
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • planobispora rosea (bacteria)
KeywordsANTIBIOTIC / Enzyme / thiopeptide / RiPP / biosynthesis.

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