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| Title | Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/ beta-catenin signaling. |
|---|---|
| Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 119, Page e2207327119-e2207327119, Year 2022 |
| Publish date | Jun 21, 2021 (structure data deposition date) |
Authors | Hansen, S. / Zhang, Y. / Hwang, S. / Nabhan, A. / Li, W. / Fuhrmann, J. / Kschonsak, Y. / Zhou, L. / Nile, A.H. / Gao, X. ...Hansen, S. / Zhang, Y. / Hwang, S. / Nabhan, A. / Li, W. / Fuhrmann, J. / Kschonsak, Y. / Zhou, L. / Nile, A.H. / Gao, X. / Piskol, R. / de Sousa E Melo, F. / de Sauvage, F.J. / Hannoush, R.N. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:36343233 |
| Methods | X-ray diffraction |
| Resolution | 1.6 Å |
| Structure data | ![]() PDB-7nam: |
| Chemicals | ![]() ChemComp-NA: ![]() ChemComp-HOH: |
| Source |
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Keywords | SIGNALING PROTEIN / LRP6 / Wnt signaling / cystine knot peptide |
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homo sapiens (human)
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