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TitleTargeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains.
Journal, issue, pagesNat. Biotechnol., Vol. 41, Page 541-551, Year 2023
Publish dateJul 8, 2021 (structure data deposition date)
AuthorsSpeltz, T.E. / Qiao, Z. / Swenson, C.S. / Shangguan, X. / Coukos, J.S. / Lee, C.W. / Thomas, D.M. / Santana, J. / Fanning, S.W. / Greene, G.L. / Moellering, R.E.
External linksNat. Biotechnol. / PubMed:36302987
MethodsX-ray diffraction
Resolution2.69 Å
Structure data

PDB-7rcu:
Synthetic Max homodimer mimic in complex with DNA
Method: X-RAY DIFFRACTION / Resolution: 2.69 Å

Chemicals

ChemComp-V7J:
2-(2,5-dioxopyrrolidin-1-yl)acetamide

ChemComp-D5M:
2'-DEOXYADENOSINE-5'-MONOPHOSPHATE

ChemComp-ACM:
ACETAMIDE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSCRIPTION / synthetic protein / complex / transcription factor mimic / DNA BINDING PROTEIN

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