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Title | Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease. |
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Journal, issue, pages | Molecules, Vol. 27, Year 2022 |
Publish date | Sep 12, 2022 (structure data deposition date) |
Authors | Huang, B. / Ghatge, M.S. / Donkor, A.K. / Musayev, F.N. / Deshpande, T.M. / Al-Awadh, M. / Alhashimi, R.T. / Zhu, H. / Omar, A.M. / Telen, M.J. ...Huang, B. / Ghatge, M.S. / Donkor, A.K. / Musayev, F.N. / Deshpande, T.M. / Al-Awadh, M. / Alhashimi, R.T. / Zhu, H. / Omar, A.M. / Telen, M.J. / Zhang, Y. / McMahon, T.J. / Abdulmalik, O. / Safo, M.K. |
External links | Molecules / PubMed:36296435 |
Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | PDB-8egi: |
Chemicals | ChemComp-CMO: ChemComp-HEM: ChemComp-VZN: ChemComp-HOH: |
Source |
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Keywords | OXYGEN TRANSPORT / Hemoglobin / sickle cell disease / antisickling / nitric oxide / oxygen equilibrium curve |